Table 3.
Summary of findings.
| PA for lung function | ||||||
|---|---|---|---|---|---|---|
|
Patient or population:
children with asthma Settings: outpatient Intervention: PA | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) |
Relative effect
(95% CI) |
No of Participants
(studies) |
Quality of the evidence
(GRADE) |
Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Lung function | |||||
| lung function - FEV1 |
The mean lung function - FEV1 in the intervention groups was
3.86 higher (1.15 to 6.58 higher) |
292
(6 studies) |
⊕⊕⊕⊝ moderate1 |
MD 3.17 (−2.82 to 9.15) | ||
| lung function - FVC |
The mean lung function - FVC in the intervention groups was 8.16 higher (5.1 to 11.21 higher) |
292
(6 studies) |
⊕⊕⊕⊝ moderate1 |
MD 7.62 (3.46 to 11.78) | ||
| lung function - FEV1/FVC |
The mean lung function - FEV1/FVC in the intervention groups was
0.84 higher (1.51 lower to 3.2 higher) |
224
(4 studies) |
⊕⊕⊕⊝ moderate1 |
MD 0.73 (−2.76 to 4.22) | ||
| lung function - FEF25 −75 |
The mean lung function - FEF25−75
in the intervention groups was 10.39 higher (2.96 to 17.82 higher) |
158
(2 studies) |
⊕⊕⊕⊝ moderate1 |
MD 10.39 (2.96 to 17.82) | ||
| lung function - PEF |
The mean lung function - PEF in the intervention groups was
0.44 higher (6.71 lower to 7.58 higher) |
134
(2 studies) |
⊕⊕⊕⊝ moderate1 |
MD 0.44 (−6.71 to 7.58) | ||
|
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). PA: Physical activity; CI: Confidence interval; FEV1: forced expiratory volume in the first second; FVC: forced vital capacity; FEF25−75: forced expiratory flow between 25% and 75% of forced vital capacity; PEF: peak expiratory flow. | ||||||
|
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
| 1 not fully blind | ||||||
| PA for QoL | ||||||
|
Patient or population:
children with asthma Settings: outpatient Intervention: PA | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) |
Relative effect
(95% CI) |
No of Participants
(studies) |
Quality of the evidence
(GRADE) |
Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | QoL | |||||
| PAQLQ - Overall |
The mean PAQLQ - overall in the intervention groups was
1.38 standard deviations higher (0.26 to 2.5 higher) |
298
(5 studies) |
⊕⊕⊝⊝ low1,2 |
SMD 1.38 (0.26 to 2.5) | ||
| PAQLQ - Symptoms |
The mean PAQLQ - symptoms in the intervention groups was
1.4 standard deviations higher (0.22 to 2.57 higher) |
298
(5 studies) |
⊕⊕⊝⊝ low1,2 |
SMD 1.4 (0.22 to 2.57) | ||
| PAQLQ - Activity limitation |
The mean PAQLQ - activity limitation in the intervention groups was
1.37 standard deviations higher (0.18 to 2.56 higher) |
298
(5 studies) |
⊕⊕⊝⊝ low1,2 |
SMD 1.37 (0.18 to 2.56) | ||
| PAQLQ - Emotions function |
The mean PAQLQ - emotions function in the intervention groups was
1.35 standard deviations higher (0.34 to 2.36 higher) |
298
(5 studies) |
⊕⊕⊝⊝ low1,2 |
SMD 1.35 (0.34 to 2.36) | ||
|
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). PA: Physical activity; QoL: quality of life; CI: Confidence interval; PAQLQ: the Pediatric Asthma Quality of Life Questionnaire | ||||||
|
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
|
1
not fully blind
2 subjective parameter | ||||||
| PA for FeNO | ||||||
|
Patient or population:
children with asthma Settings: outpatient Intervention: PA | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) |
Relative effect
(95% CI) |
No of Participants
(studies) |
Quality of the evidence
(GRADE) |
Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | FeNO | |||||
| FeNO |
The mean FeNO in the intervention groups was
1.74 lower (11.36 lower to 7.88 higher) |
128
(2 studies) |
⊕⊕⊕⊝ moderate1 |
MD −1.74 (−11.36 to 7.88) | ||
|
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). PA: Physical activity; FeNO: Fractional exhaled nitric oxide; CI: Confidence interval; | ||||||
|
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
| 1 not fully blind | ||||||