Table 1.
Overview of all so-far characterized and proposed encapsulin systems organized by family, cargo type, proposed function, number of computationally identified operons, and status (confirmed as encapsulin or not)
| Family | Cargo/enzyme component | Proposed function | Number of putative operons (18) |
Status |
|---|---|---|---|---|
| 1 | DyP | Oxidative stress resistance | 1,505 | Confirmed (35, 63, 81, 150, 151) |
| Flp | Oxidative stress resistance/iron storage | 549 | Confirmed (11, 15, 16, 58, 59, 65-67, 75, 151-154) | |
| IMEF | Iron storage/oxidative stress resistance | 101 | Confirmed (23, 36) | |
| Fusion-Flp | Oxidative stress resistance/iron storage | 69 | Confirmed (68, 69) | |
| Hemerythrin | Oxidative/nitrosative stress resistance | 45 | Confirmed (23) | |
| Bacterioferritin | Iron storage/oxidative stress resistance | 15 | Putative | |
| Fusion-cytochrome c | Anaerobic ammonium oxidation/stress resistance | 9 | Confirmed (23, 84) | |
| 2 | Cysteine desulfurase | Sulfur metabolism | 1,480 | Confirmed (17) |
| Terpene cyclase | Isoprenoid biosynthesis | 912 | Putative | |
| Polyprenyl transferase | Isoprenoid biosynthesis | 900 | Putative | |
| Terpene cyclase + polyprenyl transferase | Isoprenoid biosynthesis | |||
| Xylulose kinase | Xylose utilization | 124 | Putative | |
| 3 | Variable biosynthetic enzymes | Peptide/polyketide natural product biosynthesis | 132 | Putative |
| 4 | DeoC | Nucleotide utilization | 32 | Putative |
| OsmC | Oxidative stress resistance | 29 | Putative | |
| GAPDH | Gluconeogenesis | 10 | Putative | |
| [NiFe] sulfhydrogenase | Hydrogen metabolism | 9 | Putative |
Abbreviations: DeoC, deoxyribose-phosphate aldolase; DyP, dye-decolorizing peroxidase; Flp, ferritin-like protein; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IMEF, iron-mineralizing encapsulin-associated firmicute cargo; OsmC, osmotically inducible protein C.