Table 2.

Performance characteristics of sepsis score across cohorts for predicting 28-day mortality

Score	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	Unadjusted bivariate Cox model C-statistic (95% CI)	Adjusted* Cox model C-statistic (95% CI)	P value (Wald test)
Age and sex	–	–	–	–	–	0.59 (0.53 to 0.64)
MEWS ≥4*	0.73 (0.63 to 0.82)	0.45 (0.40 to 0.49)	0.21 (0.16 to 0.26)	0.89 (0.85 to 0.93)	0.59 (0.54 to 0.63)	0.63 (0.58 to 0.68)	0.002†
NEWS ≥5*	0.86 (0.77 to 0.93)	0.43 (0.38, to 0.48)	0.25 (0.23 to 0.28)	0.93 (0.89 to 0.95)	0.65 (0.64 to 0.67)	0.68 (0.64 to 0.73)	<0.001†
qSOFA ≥2*	0.54 (0.44 to 0.65)	0.80 (0.76 to 0.84)	0.35 (0.27 to 0.44)	0.90 (0.87 to 0.93)	0.66 (0.61 to 0.71)	0.70 (0.64 to 0.75)	<0.001†
SIRS ≥2*	0.89 (0.80 to 0.94)	0.19 (0.16 to 0.23)	0.17 (0.14 to 0.21)	0.90 (0.82 to 0.95)	0.53 (0.50 to 0.57)	0.60 (0.54 to 0.65)	0.134
UVA≥2*	0.74 (0.64 to 0.83)	0.70 (0.65 to 0.74)	0.33 (0.27 to 0.40)	0.93 (0.90 to 0.95)	0.70 (0.65 to 0.74)	0.73 (0.68 to 0.78)	<0.001†

P values are from Wald test of the adjusted Cox regression model.

*Adjusted Cox model C-statistic is adjusted for age and gender.

†Significant at p<0.002.

MEWS, Modified Early Warning Score; NEWS, National Early Warning Score; NPV, Negative predictive value; PPV, Positive predictive value; qSOFA, quick Sequential Organ Failure Assessment; SIRS, Systemic Inflammatory Response Syndrome; UVA, Universal Vital Assessment.