Figure 3.
Gene expression profile of DSS-induced UC in mice. (A) Volcano plot of differentially expressed genes. X axis: log 2 FC; Y axis: -log10 (FDR). Red represents upregulated genes, and blue represents downregulated genes. (B) GO term analysis of BP, MF, and CC for the genes. The minus logarithm of the P value (x-axis) indicates the significance of the gene set belonging to predefined categories under the coexpression network gene background. The y-axis represents each GO category. (C) A heatmap depicting the gene expression profiles of vitamin B6 metabolism and the pertussis signalling pathway in the colon of the DSS mouse model and healthy controls. X axis: sample name; Y axis: gene name. (D) Enriched upregulated and downregulated genes, as determined by KEGG pathway analysis.