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. 2023 Feb 8;14:1084494. doi: 10.3389/fneur.2023.1084494

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Copyright © 2023 Zhang, Xian, Zhao, Luo, Xie, Tian and Cong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothesis mechanism diagram of BPA mice. Anxiety-like behavior appeared in the BPA mice, which may be related to the disturbance of intestinal flora and the changes in metabolites after BPA. Through sequencing, we found that a variety of microbiota and its related metabolites involved in the anxiety inhibition decreased significantly, especially Lactobacillus_reuteri. The anxiety-like behavior after BPA can be significantly improved by the addition of intestinal psychoprobiotics, but the specific mechanism of brain-gut axis regulation still needs to be further explored.