Table 2.
Microfluidic fabrication of microfibers used as scaffolds for tissue engineering applications.
| Biomaterial | Microfluidic Design | Cross-Linking Strategy | Tissue Engineering Application | Ref. |
|---|---|---|---|---|
| Alginate, Alginate/gelatin, Alginate/urinary bladder matrix |
One-inlet straight channel microchip, two-inlet straight channel microchip, two-inlet shake micromixing chip | Ionic | Bone | [53] |
| Alginate | Flow-focusing (T junction) | Ionic | Cartilage | [54] |
| Alginate and chitosan | Four channels chip | Ionic | Liver | [55] |
| Alginate | Flow-focusing | Ionic | Liver | [56] |
| Chitosan | Co-axial | Liver | [57] | |
| Collagen/alginate | Co-axial | Ionic | Pancreas | [58] |
| Alginate | Co-axial | Ionic | Microvasculature | [59] |
| Alginate | Co-axial | Ionic | Nerve | [60] |
| Alginate | Flow-focusing | Ionic | Nerve | [61] |
| Alginate, PNIPAAM-co-sodium acrylate, PNIPAAm-co-allyl amine | Co-axial flow | Ionic + Photopolymerization | General | [62] |
| Collagen, fibrin | Double co-axial flow | Physical | General | [63] |
| Alginate/GelMA | Two-flow | Ionic + Photochemical | General | [64] |