Table 2. Demographic Characteristics by APOE Genotype in the 3 Study Stage Samples.
| Characteristics | ADSP discovery (stage 1) | ADGC replication (stage 2) | MVP validation (stage 3) | |||
|---|---|---|---|---|---|---|
| Alzheimer disease cases | Cognitively healthy controls | Alzheimer disease cases | Cognitively healthy controls | Alzheimer disease cases | Cognitively healthy controls | |
| No. of individuals | 2888 | 4957 | 1201 | 2744 | 733 | 19 406 |
| Sex, No. (%) | ||||||
| Female | 1984 (68.7) | 3570 (72.0) | 831 (69.2) | 1882 (68.6) | 22 (3.0) | 1074 (5.5) |
| Male | 904 (31.3) | 1387 (28.0) | 370 (30.8) | 862 (31.4) | 711 (97.0) | 18 331 (94.5) |
| Age, median (IQR), y | 77.0 (71.0-83.0) | 77.0 (71.0-83.0) | 75.0 (69.0-81.0) | 80.0 (75.0-84.0) | 79.4 (73.8-86.5) | 71.9 (68.4-75.8) |
| APOE ε2/ε2 genotype | ||||||
| No. (%) | 11 (0.4) | 41 (0.8) | 5 (0.4) | 26 (0.9) | 1 (0.013) | 231 (1.2) |
| Age, median (IQR), y | 81.0 (78.0-85.5) | 78.0 (72.0-85.0) | 79.0 (73.0-80.0) | 82.5 (80.0-85.0) | 84.8 (84.3-84.83) | 71.6 (68.2-75.6) |
| APOE ε2/ε3 genotype | ||||||
| No. (%) | 225 (7.8) | 709 (14.3) | 76 (6.3) | 377 (13.7) | 60 (8.2) | 2935 (15.1) |
| Age, median (IQR), y | 81.0 (75.0-86.0) | 78.0 (71.0-85.0) | 79.0 (72.5-83.0) | 81.0 (77.0-85.0) | 79.0 (73.5-85.8) | 72.1 (68.6-76.4) |
| APOE ε3/ε3 genotype | ||||||
| No. (%) | 1145 (39.6) | 2622 (52.9) | 430 (35.8) | 1318 (48.0) | 247 (33.7) | 9335 (48.1) |
| Age, median (IQR), y | 79.0 (73.0-84.0) | 77.0 (71.0-84.0) | 77.0 (70.25-83.0) | 80.0 (74.0-84.0) | 81.4 (74.4-87.9) | 71.9 (68.4-76.0) |
| APOE ε2/ε4 genotype | ||||||
| No. (%) | 111 (3.8) | 179 (3.6) | 42 (3.5) | 120 (4.4) | 37 (5.0) | 803 (4.1) |
| Age, median (IQR), y | 78.0 (72.0-85.0) | 75.0 (69.0-82.25) | 77.0 (72.0-82.75) | 81.0 (76.0-85.0) | 80.26 (74.9-87.2) | 71.6 (68.6-75.3) |
| APOE ε3/ε4 genotype | ||||||
| No. (%) | 1093 (37.8) | 1288 (26.0) | 491 (40.9) | 786 (28.6) | 289 (39.4) | 5422 (27.9) |
| Age, median (IQR), y | 76.0 (70.0-81.0) | 76.0 (70.0-82.0) | 75.0 (69.0-80.0) | 80.0 (74.0-84.0) | 79.3 (73.4-86.2) | 71.7 (68.5-75.4) |
| APOE ε4/ε4 genotype | ||||||
| No. (%) | 303 (10.5) | 118 (2.4) | 157 (13.1) | 117 (4.3) | 99 (13.5) | 679 (3.5) |
| Age, median (IQR), y | 71.0 (65.0-76.0) | 73.0 (67.0-78.0) | 71.0 (66.0-77.0) | 78.0 (71.0-83.0) | 77.5 (72.7-82.9) | 71.1 (67.8-74.1) |
Abbreviations: ADGC, Alzheimer Disease Genetic Consortium; ADSP, Alzheimer Disease Sequencing Project; MVP, Million Veteran Program.