Table 1.
Candidate vaccine | Vaccine platform description | Developer | Number of doses | Schedule | Route of administration | Storage temperature | Number of approved countries | Potential serious side effects |
mRNA-1273 (Spikevax) | mRNA | Moderna | 2 | Day 0 + 28 | Intramuscular | 2–8°C for 30 days, −20°C for 6 months | 88 | Myocarditis and pericarditis |
BNT162b2 (Comirnaty) | mRNA | Pfizer/BioNTech | 2 | Day 0 + 21 | Intramuscular | −70°C | 148 | – |
COVOVAX (Novavax formulation) | Protein subunit | Serum Institute of India | 2 | Day 0 + 21 | Intramuscular | 2–8°C | 5 | – |
Nuvaxovid | Protein subunit | Novavax | 2 | Day 0 + 21 | Intramuscular | 2–8°C | 39 | – |
Ad5-nCov (Convidecia) | Replication-defective adenovirus type 5 vector | CanSino | 2 | Day 0 + 21 | Intramuscular | 2–8°C | 10 | Thrombotic thrombocytopenia syndrome |
Ad26.COV2.S | Replication-incompetent human adenovirus type 26 vector | Janssen (Johnson & Johnson) | 1–2 | Day 0 or Day 0 + 56 | Intramuscular | 2–8°C | 113 | Thrombotic thrombocytopenia syndrome and Guillain-Barré syndrome |
AZD1222 (Vaxzevria) | Replication-defective chimpanzee adenovirus vector | Oxford/AstraZeneca | 1–2 | Day 0 or Day 0 + 28 | Intramuscular | 2–8°C | 148 | Thrombotic thrombocytopenia syndrome and Guillain-Barré syndrome |
Covishield | Replication-defective chimpanzee adenovirus vector | Serum Institute of India | 1–2 | Day 0 or Day 0 + 28 | Intramuscular | 2–8°C | 49 | Thrombotic thrombocytopenia syndrome and Guillain-Barré syndrome |
Covaxin | Inactivated | Bharat Biotech | 2 | Day 0 + 14 | Intramuscular | 2–8°C | 14 | – |
BBIBP-CorV (Covilo) | Inactivated | Sinopharm (Beijing) | 2 | Day 0 + 21 | Intramuscular | 2–8°C | 93 | – |
CoronaVac | Inactivated | Sinovac | 2 | Day 0 + 14 | Intramuscular | 2–8°C | 56 | – |
COVID-19: Coronavirus disease 2019; mRNA: Messenger ribonucleic acid; WHO: World Health Organization. https://covid19.trackvaccines.org/agency/who/.