Table 3. Multivariable Cox Regression Analysis Results for Overall Survival.
| Characteristics | aHR (95% CI) | P value |
|---|---|---|
| Income | ||
| Above median | 1 [Reference] | [Reference] |
| Below median | 1.18 (1.11-1.25) | <.001 |
| Race | ||
| Non-Hispanic White | 1 [Reference] | [Reference] |
| Hispanic White | 0.8 (0.72-0.90) | <.001 |
| Black | 1.08 (1.00-1.18) | .05 |
| Asian and Pacific Islander | 0.66 (0.56-0.79) | <.001 |
| Age, y | ||
| <50 | 1 [Reference] | [Reference] |
| ≥50 | 1.96 (1.77-2.17) | <.001 |
| Facility | ||
| Nonacademic | 1 [Reference] | [Reference] |
| Academic | 0.79 (0.75-0.84) | <.001 |
| Insurance | ||
| None | 1 [Reference] | [Reference] |
| Private | 0.64 (0.51-0.81) | <.001 |
| Government | 1.49 (1.19-1.87) | <.001 |
| Educationa | ||
| Above median | 1 [Reference] | [Reference] |
| Below median | 1.06 (1.00-1.12) | .046 |
| CDS | ||
| 0 | 1 [Reference] | [Reference] |
| 1 | 1.58 (1.49-1.68) | <.001 |
| ≥2 | 2.69 (2.47-2.94) | <.001 |
| Year | ||
| For every 1 y increase | 1.01 (1.00-1.03) | .07 |
| Histology | ||
| Ductal or lobular carcinoma | 1 [Reference] | [Reference] |
| Other | 0.98 (0.91-1.05) | .53 |
| PR | ||
| Positive | 1 [Reference] | [Reference] |
| Negative | 1.1 (1.02-1.18) | .01 |
| RS | ||
| 0-25 | 1 [Reference] | [Reference] |
| >25 | 1.91 (1.77-2.05) | <.001 |
| T staging | ||
| 1 | 1 [Reference] | [Reference] |
| 2 | 1.52 (1.45-1.61) | <.001 |
| 3 | 2.34 (1.99-2.75) | <.001 |
| N staging | ||
| 0 | 1 [Reference] | [Reference] |
| 1a | 1.61 (1.51-1.71) | <.001 |
| Grade | ||
| 1 | 1 [Reference] | [Reference] |
| 2 | 1.13 (1.07-1.21) | <.001 |
| 3 | 1.49 (1.37-1.61) | <.001 |
| Other | 0.86 (0.36-2.07) | .74 |
| LVSI | ||
| No | 1 [Reference] | [Reference] |
| Yes | 1.14 (1.07-1.23) | <.001 |
| Chemotherapy | ||
| No | 1 [Reference] | [Reference] |
| Yes | 0.71 (0.66-0.76) | <.001 |
| Radiation | ||
| No | 1 [Reference] | [Reference] |
| Yes | 0.59 (0.55-0.64) | <.001 |
| Surgery | ||
| Lumpectomy | 1 [Reference] | [Reference] |
| Mastectomy | 0.71 (0.65-0.77) | <.001 |
| Other | 1.46 (0.55-3.90) | .45 |
| Margin | ||
| Negative | 1 [Reference] | [Reference] |
| Positive | 1.19 (1.05-1.36) | .007 |
Abbreviations: aHR, adjusted hazards ratio; CDS, Charlson-Deyo comorbidity score; LVSI, lymphovascular space invasion; PR, progesterone receptor; RS, 21-gene recurrence score.
a
Median education level was 10.9% of adults living in a zip code who did not graduate from high school.