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Topology of somatic hypermutation in IgA versus IgG multiple myeloma. Ratio of replacement to silent mutations (R:S) in the VH FRs and VH CDRs in cases expressing the 4 commonly frequent IGHV genes of MM patients with IgG and IgA isotypes: IGHV3-23 (A), IGHV3-30 (B), IGHV4-59 (C) and IGHV3-9 (D). Asterisks indicate the statistically significant differences between the VH FR and VH CDR regions (p-value ≤ 0.05(*), p-value ≤ 0.01 (**) and p-value ≤ 0.001 (***)).
