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. 2023 Feb 8;11:1127594. doi: 10.3389/fcell.2023.1127594

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Copyright © 2023 Huang, Kang, Leung, Lu, Shirazi, Gajendrareddy and Ravindran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endocytosis of EVs by MSCs. (A) Representative confocal micrographs of fluorescently labeled (green) control and 424 EVs endocytosed by HMSCs. Red represents actin counter stain, and the nuclei are stained blue with DAPI. Scale bar represents 20 μm. (B) Dose-dependent endocytosis of fluorescently labeled control and 424 EVs by HMSCs. No significant difference was observed between the ability of the two EVs to be endocytosed by HMSCs. Data are represented as mean ( ± SD).