Figure 6.

TBvac-1 and TBvac-2 reduced bacterial load in mouse lungs in a virulent Mtb infection model. (A) Illustration of the experimental procedure to evaluate the virus-induced protective efficacy in mice. Mice (n=4-5) were immunized (IM) through prime-boost strategy with vector or TBvac-1 or TBvac-2, and, 28 days later, challenged with virulent Mtb. (B) Tissues (lungs and spleens) were collected at 4 and 12 weeks after challenge to determine viable Mtb CFU by plating of tissue homogenates. Statistical analysis was conducted with unpaired t-test. **p < 0.01; *p < 0.05; ns, not significant.