Table 4.
Cardiometabolic profile in prepubertal obese patients according to optimal cutoff values of SPISE to predict IR (6.3) and MetS (5.7).
| Insulin Resistance | Metabolic Syndrome | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | SPISE ≤ 6.3 (n=173) |
SPISE > 6.3 (n=259) |
Mean diff | ES for diff† | SPISE ≤ 5.7 (n=118) |
SPISE > 5.7 (n=314) |
Mean diff | ES for diff† |
| Waist circumference (mm Hg) | 91.0 ± 9.0*** | 78.6 ± 7.5 | 12.4 | 1.52 | 93.6 ± 9.4*** | 79.8 ± 8.0 | 13.8 | 1.40 |
| Systolic Blood Pressure (mm Hg) | 109 ± 13*** | 101 ± 10 | 8.0 | 0.71 | 109 ± 13*** | 102 ± 10 | 7.6 | 0.64 |
| Diastolic Blood Pressure (mm Hg) | 69 ± 9*** | 65 ± 8 | 4.0 | 0.48 | 69 ± 9*** | 64 ± 8 | 4.7 | 0.60 |
| Fasting Glucose (mg/dl) | 87.3 ± 8.9 | 86.1 ± 9.0 | 1.2 | does not apply | 87.2 ± 9.1 | 86.1 ± 9.0 | 1.1 | does not apply |
| Fasting Insulin (uUI/dl) | 12.0 (9.1)*** | 6.7 (4.9) | 5.3 | 0.77‡ | 13.2 (10.1) *** | 7.0 (6.4) | 5.2 | 0.81‡ |
| HOMA-IR | 2.6 (2.3)*** | 1.4 (1.2) | 1.2 | 0.68‡ | 3.0 (2.4) *** | 1.5 (1.3) | 1.5 | 0.88‡ |
| HOMA-S (%) | 38.5 (40.3) *** | 71.4 (63.4) | -32.9 | 0.60‡ | 33.3 (34.4) *** | 66.6 (65.6) | 33.3 | 0.57‡ |
| HOMA-β (%) | 194 (157) *** | 107 (132) | 87 | 0.61‡ | 207 (155) *** | 116 (141) | 91 | 0.63‡ |
| Disposition Index | 0.72 (0.4) | 0.75 (0.4) | 0.03 | does not apply | 0.72 (0.3) | 0.75 (0.3) | 0.03 | does not apply |
| Total Cholesterol (mg/dl) | 176.1 ± 34.1* | 168.6 ± 30.5 | 7.5 | 0.24 | 178.0 ± 32.2** | 167.5 ± 31.9 | 10.5 | 0.33 |
| HDL-cholesterol (mg/dl) | 42.1 ± 9.1*** | 51.1 ± 9.7 | -9.0 | 0.95 | 41.6 ± 10.6*** | 50.1 ± 10.6 | -8.5 | 0.80 |
| LDL-cholesterol (mg/dl) | 108.1 ± 29.1 | 102.7 ± 29.3 | 5.4 | does not apply | 109.5 ± 27.2 | 103.1 ± 29.1 | 6.4 | does not apply |
| TG-HDL ratio | 4.1 (1.4) *** | 3.3 (1.1) | 0.8 | 0.65‡ | 4.3 (1.2)*** | 3.3 (1.0) | 1.0 | 0.95‡ |
| Triglycerides (mg/dl) | 118.0 (80.1)*** | 73.6 (42.9) | 44.4 | 0.73 | 135.7 ± 82.6*** | 77.0 ± 47.5 | 66.2 | 0.99 |
Values expressed as mean ± SD and median (IQR). Two-tailed Student’s t test for independent samples. Wilcoxson Rank-sum test. *Significant at P<0.05. ** Significant at P<0.01. *** Significant at P<0.001. †Cohen’s d statistic (normal distributions), except as indicated. ‡Cliff’s δ (non-normal distributions). Values of d of 0.20, 0.50 and 0.80 denote small, medium and large differences. Values of δ are considered small around 0.15, medium around 0.33, and large around 0.47.