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. 2023 Feb 8;14:1106771. doi: 10.3389/fimmu.2023.1106771

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Copyright © 2023 Xu, Wang, Guo, Chen, Ding, Zou, Zhu, Li and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NSC12 relieves endometriosis-induced hyperalgesia in vivo. (A) Protein expression of p-FGFR1in DRG cells after different interventions. (B) Relative level of p-FGFR1 expression (n = 3 in each group). (C) Schematic of animal intervention. (D) Mechanical threshold after different interventions (n = 6 in each group). (E) Thermal latency after different interventions (n = 6 in each group). (F–H) The Representative images of p-FGFR1 staining in DRG tissue, 400×, bar = 20 μm. I The Relative expression of p-FGFR1 in DRG tissues different intervention group (n = 6, 6, 5). Sham: sham operation group, EMS, endometriosis model; NSC12, endometriosis model establishment and NSC12 intervention. *P < 0.05, **P < 0.01.