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. 2023 Feb 8;14:1106771. doi: 10.3389/fimmu.2023.1106771

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Copyright © 2023 Xu, Wang, Guo, Chen, Ding, Zou, Zhu, Li and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the present findings. High concentration of estrogen in local endometriotic environment could promote the secretion of FGF2 through GPR30 via MEK/ERK pathway in mast cells. Enhanced level of FGF2 by mast cells in ovarian endometriotic lesion may aggravated endometriosis-related pain.