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. 2023 Feb 8;14:1108116. doi: 10.3389/fimmu.2023.1108116

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Copyright © 2023 Müller-Jensen, Knauss, Ginesta Roque, Schinke, Maierhof, Bartels, Finke, Rentzsch, Ulrich, Mohr, Stenzel, Endres, Boehmerle and Huehnchen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CONSORT diagram. Between September 2017 and January 2022, a total of 86 cancer patients were enrolled for the study. After application of inclusion and exclusion criteria, 73 patients were included. As two patients that were originally allocated to the control cohort developed irAE-n, a total of 29 irAE-n patients and 44 cancer control patients were analyzed. CSF, cerebrospinal fluid; ICI, immune checkpoint inhibitor; irAEs, immune related adverse events; irAE-n, neurological immune related adverse event.