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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Acta Neuropathol. 2022 Jun 17;144(2):187–210. doi: 10.1007/s00401-022-02449-w

Figure 5.

Figure 5.

Repeated mild CHI-impaired long-term potentiation (LTP) and expression of synaptic proteins are alleviated by silencing of TDP-43 in WT mice. (a~c) LTP at hippocampal CA3-CA1 synapses in WT mice that received LV expressing Scramble control, TDP-43-shRNA, or shRNA-resistant TDP-43. Recordings were made 30 days following three repeated mCHI. The data in bar graphs are means ±SEM averaged from 56 to 60 min following high-frequency stimulation (HFS). ANOVA with Bonferroni post-hoc test, n=12~15 slices/5~7 animals/group). (d~f) Expression of glutamate receptor subunits and PSD-95 in the hippocampus of WT mice that received LV expressing Scramble control, TDP-43-shRNA, or shRNA-resistant TDP-43. The analysis was performed 30 days after repeated mCHI. The data are means ±SEM. *P<0.05, **P<0.01, ***P<0.001 compared with Sham, (ANOVA with Fisher's PLSD test post-hoc test, n=6 animals/group).