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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Acta Neuropathol. 2022 Jun 17;144(2):187–210. doi: 10.1007/s00401-022-02449-w

Figure 7.

Figure 7.

Knockdown of TDP-43 prevents repeated mild CHI-induced cognitive decline in WT mice. a, NOR test in animals that received LV expressing Scramble control. The test was conducted 30 days after three mild CHI. The data are means ±SEM (ANOVA with Bonferroni post-hoc test, n=11~14 animals/group). b, MWM test in animals that received expressing Scramble control. The data are means ±SEM (ANOVA with repeated measures). The probe test was conducted 24 hours after 7-day learning acquisition training. The data are means ±SEM (ANOVA with Bonferroni post-hoc test). c, NOR test in animals that received LV expressing TDP-43-shRNA. The data are means ±SEM (n=11~14 animals/group). d, MWM test in animals that received LV expressing TDP-43-shRNA. The data of the probe test are means ±SEM. e, NOR test in WT mice that received LV expressing shRNA-resistant TDP-43. The data are means ±SEM (ANOVA with Bonferroni post-hoc test, n=22~25 animals/group). f, MWM test in WT mice that received LV expressing shRNA-resistant TDP-43. The data are means ±SEM (ANOVA with repeated measures, n=11~12 animals/group). The probe test was conducted 24 hours after 7-day learning acquisition training. The data are means ±SEM (ANOVA with Bonferroni post-hoc test).