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. 2023 Feb 1;11:1103719. doi: 10.3389/fcell.2023.1103719

FIGURE 6.

FIGURE 6

Human fetal pancreas functional maturation corresponds with increased maturation marker expression. Transplanted HFP was monitored for in vivo function through IP-GTT. (A) Representative images of the graft on the day of transplantation (Day 0 Graft) and after 32 weeks. Scale = 0.5 cm. (B) Blood glucose values during IP-GTT at 12, 25, and 32 weeks post-transplantation compared to diabetic non-transplanted controls. (C) Area under the curve (AUC) values for the IP-GTT curves. Gray asterisks indicate statistical comparison to the diabetic control, while light purple asterisks indicate statistical comparison to Week 12. (D) Serum human C-peptide levels in fasted and stimulated (15 min after glucose injection) states. (E) Representative images of immunofluorescent staining of 32 weeks grafts for maturation markers (in red) CHGB (a), G6PC2 (b), IAPP (c), GLUT1 (d), MAFA (e), FAM159B (f). Scale = 50 microns. (ns = not significant, **p < 0.01, ***p < 0.001).