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. 2023 Feb 21;14:10. doi: 10.1186/s13293-023-00493-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Total adiponectin expression shows sex differences; leptin is regulated by diet but not sex. a Serum/circulating adiponectin levels were significantly higher in females compared to males (^amain effect of sex, F_{(1, 31)} = 55.00, p < 0.0001), however, there was no main effect of diet treatments (F_{(2, 31)} = 0.5945, p = 0.5580); Two-way ANOVA, Tukey's multiple comparisons test; *p < 0.05. b Cochlear adiponectin levels were measured in the whole cochlear lysates. Dietary fat treatment increased cochlear adiponectin level only in female mice, but not in male mice. Two-way ANOVA, Fisher's LSD; ^amain effect of sex, F_{(1, 33)} = 13.24, p = 0.0009; ^bmain effect of diet, F_{(2, 33)} = 4.303, p = 0.0218. c Serum/circulating leptin level showed a significant increase in HFD-fed mice compared to control diet. Two-way ANOVA; Tukey's multiple comparisons test; ^amain effect of sex, F_{(1, 28)} = 2.437, p = 0.1298; ^bmain effect of diet, F_(2,28) = 17.81, p < 0.0001; *p < 0.05. d Cochlear leptin level showed no significant differences among groups. Main effect of sex, F_{(1, 31)} = 2.249, p = 0.1438; main effect of diet, F_(2,31) = 0.1752, p = 0.8401, ns not significant