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. 2023 Feb 22;10:7. doi: 10.1186/s40779-023-00441-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Cell diversity in mice liver cells delineated by single-cell transcriptome. a UMAP visualization of 13 cell types based on 76,209 single-cell transcriptomes. Cell counts for each individual cell type are indicated in parentheses. Each dot represents a single cell. b Violin plots showing the expression levels of representative markers in each cell type. c Distribution of each cell type in control and TCS-200 groups. The bar chart showed the relative fraction of each cell type in different groups. d Heatmap of transcription factor (TF) activities in each cell type. UMAP Uniform Manifold Approximation and Projection for Dimension Reduction, Endos endothelial cells, Heps hepatocytes, HSCs hepatic stellate cells, LCMs liver capsular macrophages, pDCs plasmacytoid dendritic cells, Prolif proliferative cells, T/NK T/natural killer cells, TCS triclosan, RSS regulon specificity score