Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 22;10:7. doi: 10.1186/s40779-023-00441-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Distinct endothelial cells according to the spatial locations. a UMAP visualization of the 7 distinct subtypes of Endos based on spatial distribution. b Heatmap of the expression levels of representative markers indicating generalized Endos as well as central, pericentral, middle, periportal and portal position. c Pie chart showing the fraction of each endothelial subtype. d Strip chart showing DEGs of each subtype after TCS-200 treatment. The texts in green color represents the pathways enriched in the up-regulated DEGs in LSEC_mid2. e Split violin plot of the expression levels of genes associated with endocytic receptors and vascular tone regulation. f RNA velocity analysis of different subtypes of Endos, indicating LSEC capillarization. g Scatter diagram showing RSS of TFs in LSEC_mid2 subtype. The top 5 TFs ordered by scores were listed. h Transcription regulatory network constructed by Hlf and its target genes. Red text represents TFs, black text for targets (target), pink hexagon for genes related to ECM, tissue remodeling and response to hypoxia (key target). Endos endothelial cells, LVEC liver vascular endothelial cells, LSEC liver sinusoidal endothelial cells, UMAP uniform manifold approximation and projection for dimension reduction, DEGs differentially expressed genes, TCS triclosan, ECM extracellular matrix, RSS regulon specificity score, TFs transcription factors; ***P < 0.001