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. 2023 Feb 21;14:906. doi: 10.1038/s41467-023-36484-2

Fig. 10. Working model of Slc37a2 in osteoclast function and bone metabolism.

Fig. 10

Top panel provides an overview of proteomic identification of sugar transporter Slc37a2 on osteoclast secretory lysosomes, the middle panels highlight tissue level alterations in osteoclast–osteoblast coupling during bone remodeling in Slc37a2-deficient mice and the bottom panel illustrates the proposed role for Slc37a2 in the regulation of sugar export from secretory lysosomes, a prerequisite for secretory lysosome resolution, membrane tubulation and delivery to the osteoclast ruffled border. Created with BioRender.com.