Table 5.

Narrative synthesis of included records on the HRQoL in adults with OI

domain	N	Findings	Records
Physical function	28	Physical functioning was described using a variety of tools however SF-36 (n = 13) was used most often. Included records suggest that physical functioning and independence are lower in adults with OI compared with the overall population. In all included records (n = 4), sleep was affected in individuals with OI	[31, 35, 52, 103, 109, 111, 151, 180, 201, 205, 206, 253–267]
Pain	7	Records concluded that adults with OI experienced significantly more pain and pain interference compared with the overall population	[13, 52, 106, 187, 254, 265, 268]
Fatigue	5	Included records concluded that individuals with OI experienced significantly more fatigue compared with the overall population, however women were overrepresented (62–78% of study samples)	[13, 106, 187, 254, 269]
Mental health	23	Included records on the mental health of adults with OI reached conflicting conclusions on the effect of OI on individuals’ mental health	[13, 35, 52, 106, 109, 111, 151, 205, 206, 253–262, 265–267, 270]
Social functioning	6	Records using validated tools (n = 4) found that social functioning of adults with OI was comparable with the overall population	[13, 106, 109, 206, 266, 267]

HRQoL Health-related quality of life, OI Osteogenesis imperfecta, SF-36 Short Form Questionnaire