TABLE 1.
Study population demographic and clinical characteristics.
| DCD Group (n = 11) | DBD Group (n = 110) | p-value | |
|---|---|---|---|
| Donor characteristics | |||
| Sex (Female), n (%) | 1 (9.1) | 41 (37.3) | 0.061 |
| Age, median (IQR) | 53.0 (8.5) | 49.0 (19.0) | 0.168 |
| BMI, median (IQR) | 27.7 (5.5) | 24.8 (4.4) | 0.022 a |
| Comorbidities (Yes), n (%) | 7 (63.6) | 48 (43.6) | 0.204 |
| Mechanical ventilation (days), median (IQR) | 1 (6) | 2 (3) | 0.611 |
| Smoking history, n (%) | |||
| No | 7 (63.6) | 73 (66.3) | 0.855 |
| Former | 1 (9.1) | 8 (7.3) | 0.827 |
| Yes | 3 (27.3) | 29 (26.4) | 0.948 |
| Chest X-ray, n (%) | |||
| Clear | 7 (63.6) | 69 (62.7) | 0.952 |
| Minor | 1 (9.1) | 25 (22.7) | 0.294 |
| Opacity<1 lobe | 3 (27.3) | 12 (10.9) | 0.116 |
| Opacity ≥1 lobe | 0 (0.0) | 4 (3.7) | 0.520 |
| Donor PaO2/FiO2, median (IQR) b | 372.0 (60.0) | 470.0 (137.0) | 0.07 |
| Donor secretions, n (%) | |||
| None | 5 (45.4) | 43 (39.1) | 0.681 |
| Minor | 3 (27.3) | 53 (48.2) | 0.185 |
| Moderate | 3 (27.3) | 13 (11.8) | 0.149 |
| Major | 0 (0.0) | 1 (0.9) | 0.751 |
| Sex mismatch, n (%) | 5 (45.5) | 16 (14.5) | 0.009* |
| Recipient characteristics | |||
| Sex (Female), n (%) | 6 (54.5) | 52 (47.3) | 0.645 |
| Age, median (IQR) | 42.0 (17.5) | 36.5 (24.8) | 0.836 |
| BMI, median (IQR) | 20.8 (3.2) | 20.5 (4.2) | 0.960 |
| Disease, n (%) | |||
| Cystic fibrosis | 8 (72.7) | 68 (61.9) | 0.475 |
| Interstitial lung disease | 1 (9.1) | 25 (22.7) | 0.294 |
| COPD | 2 (18.2) | 10 (9.1) | 0.336 |
| Bronchiectasis | 0 (0.0) | 3 (2.7) | 0.579 |
| Pulmonary vascular disease | 0 (0.0) | 1 (0.9) | 0.751 |
| Other | 0 (0.0) | 3 (2.7) | 0.579 |
| Urgent transplantation, n (%) | 0 (0.0) | 10 (9.1) | 0.297 |
| LAS, median (IQR) | 42.9 (9.0) | 38.5 (12.6) | 0.652 |
| PAPm, median (IQR) | 22.0 (2.0) | 24.0 (10.0) | 0.924 |
| PaCO2, median (IQR) | 48 (8) | 42 (11) | 0.362 |
| ECMO Bridge to transplantation, n (%) | 0 (0.0) | 10 (9.1) | 0.297 |
| Intraoperative | |||
| Incision, n (%) | |||
| Clamshell | 9 (81.8) | 71 (64.5) | 0.249 |
| Bilateral anterior thoracotomy | 2 (18.9) | 39 (35.5) | 0.249 |
| Machine perfusion, n (%) | 11 (100) | 17 (15.5) | <0.001 a |
| CIT, 1st lung (minutes), median (IQR) | 595 (159) | 338 (157) | <0.001 a |
| CIT, 2nd lung (minutes), median (IQR) | 820 (155) | 557 (181) | <0.001 a |
| Intraoperative WIT, 1st lung (minutes), median (IQR) | 76 (27) | 82 (29) | 0.257 |
| Intraoperative WIT, 2nd lung (minutes), median (IQR) | 80 (24) | 71 (25) | 0.539 |
| TIT, 1st lung (minutes), median (IQR) | 797 (154) | 428 (156) | <0.001 a |
| TIT, 2nd lung (minutes), median (IQR) | 1,026 (202) | 632 (186) | <0.001 a |
| TPT, 1st lung (minutes), median (IQR) | 1,058 (125) | 433 (175) | <0.001 a |
| TPT, 2nd lung (minutes), median (IQR) | 1,286 (102) | 641 (213) | <0.001 a |
| ECMO, n (%) | 7 (63.6) | 51 (46.4) | 0.274 |
| Intraoperative Red cells concentrate transfusion (U), median (IQR) | 3.0 (4) | 3.0 (5) | 0.899 |
| Intraoperative Plasma transfusion (U), median (IQR) | 1.0 (3) | 0.0 (3) | 0.778 |
| Intraoperative Platelet transfusion (U), median (IQR) | 0.0 (0) | 0.0 (0) | 0.396 |
a
Statistically significant p-value.
b
Median PaO2/FiO2 was calculated in 5 and 106 patients in the DCD and DBD Group, respectively.
BMI, body mass index; IQR, interquartile range; PaO2/FiO2, ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen; COPD, chronic obstructive pulmonary disease; LAS, lung allocation score; PAPm, mean pulmonary artery pressure; PaCO2, arterial partial pressure of carbon dioxide; ECMO, extracorporeal membrane oxygenation; CIT, cold ischemia time; WIT, warm ischemia time; TIT, total ischemia time; TPT, total preservation time; U, units.