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. 2023 Feb 22;131(2):027005. doi: 10.1289/EHP11372

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Figure 4A is a coefficient plot titled Study of Latino Adolescents at Risk, plotting Urea cycle, including N-acetylornithine; Lysine metabolism, including L-Carnitine, Aminoadipic acid, 6-Amino-2-oxohexanoate; and Arginine and proline metabolism, including Aspartic acid, 5-Amino-2-oxopentanoic acid, Citrulline, and N-Acetylputrescine (y-axis) across Per- and polyfluoroalkyl substances mixture effect uppercase psi (95 percent Bayesian credible interval), ranging from negative 1 to 2 in unit increments (x-axis) for Same direction of association in Study of Latino Adolescents at Risk and Children’s Health Study and Only significant in one cohort. Figure 4B is a coefficient plot titled Children’s Health Study, plotting Lysine metabolism, including 3-Dehydroxycarnitine and Aminoadipic acid; and Arginine and proline metabolism, including 5 prime-Methylthioadenosine (y-axis) across Per- and polyfluoroalkyl substances mixture effect uppercase psi (95 percent Bayesian credible interval), ranging from negative 1 to 2 in unit increments (x-axis) for Same direction of association in Study of Latino Adolescents at Risk and Children’s Health Study and Only significant in one cohort. — Associations between PFAS mixtures and metabolites associated with nonaromatic amino acid metabolism in (A) adolescents from the SOLAR cohort ( $lowercase italic n equals 312$ ) and (B) young adults from the CHS cohort ( $lowercase italic n equals 137$ ). Effect estimates for PFAS mixture ( $ψ$ ) and the 95% Bayesian credible interval (BCI) estimate the change in metabolite levels (SD of the log-transformed feature intensity) when increasing all PFAS in the mixture from the 30th percentile to the 70th percentile. This estimate is also equivalent to a standardized mean difference calculated between a hypothetical group of individuals with all PFAS at the $approximately 70$ th percentile vs. a hypothetical group of individuals with all PFAS at the $approximately 30$ th percentile. Corresponding $p$ -values and $q$ -values are presented in Table S4. Note: CHS, Children’s Health Study; PFAS, per- and polyfluoroalkyl substances; SD, standard deviation; SOLAR, Study of Latino Adolescents at Risk.