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. 2023 Feb 8;13:1076525. doi: 10.3389/fcimb.2023.1076525

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Copyright © 2023 Zhang, Zhang, Hu, Xu, Tang, Tang, Liu, Li, Xu, Guo and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the positive rate of metagenomic next-generation sequencing(mNGS) in spinal infection lesions and culture and analysis of the consistency of detection results. (A) The positive rate of mNGS was significantly higher than that of culture (P < 0.001). (B) Contingency tables formatted in a 2 × 2 manner showing mNGS and culture being formatted in the diagnosis of pathogens of spinal infection, because the positive rate of culture was low (18/92, 19.57%). The consistency between the two methods was poor (Kappa=0.07). (C) The pie chart shows the matching situation between mNGS and positive culture results. Among 18 positive culture samples, the culture results of 15 samples are completely consistent with mNGS. Three samples were partially consistent (at least 1 pathogen identified in the test was confirmed by the other), and there was no conflict between mNGS and culture results. mNGS, metagenomic next-generation sequencing; PPA, positive percent agreement; NPA, negative percent agreement; OPA, overall percent agreement.