Table 2.
Characteristics of the tau-PET patterns (discrete scale)
| Subtypes at baseline (N=173) | TAD (N=57) | LP (N=21) | CP (N=31) | MT (N=64) |
|---|---|---|---|---|
| AD dementia/ prodromal AD/ cognitively normal (%) | 28/42/30 | 24/24/52 | 6/32/61 | 2/17/80 |
| Typicality (mean (SD)) | 1.3 (0.3) a, b, c | 1.6 (0.3) a, b | 0.9 (0.2) a | 1.1 (0.2) |
| Severity (mean (SD)) | 1.9 (0.5) a, b, c | 1.5 (0.1) a, b | 1.6 (0.2) a | 1.3 (0.1) |
| Age at baseline (years) |
76.3 ± 7.3 [62, 90] |
76.3 ± 6.4 [65, 90] |
76.6 ± 7.8 [56, 91] |
74.9 ± 7.8 [59, 92] |
| Sex (% female) | 64.9 | 42.9 | 54.8 | 46.9 |
| Education (years) |
15.9 ± 2.3 [12, 20] a |
15.6 ± 2.6 [12, 20] a |
16.1 ± 2.4 [12, 20] |
17 ± 2.4 [12, 20] |
| APOE ε4 carriers (%) | 66.7 | 57.1 | 58.1 | 50.8 |
| Retrospective MMSE | 27.10 ± 3.15 [17, 30] a | 27.25 ± 1.75 [24, 29] a |
27.74 ± 2.40 [23, 30] a |
29 ± 1.25 [26, 30] |
| Baseline MMSE |
26.1 ± 4.3 [9, 30] a |
26.8 ± 3.1 [20, 30] a, b |
28.2 ± 2.1 [21, 30] |
28.6 ± 1.9 [17, 30] |
| Prospective MMSE |
25.6 ± 3.90 [13, 30] a, b |
26.5 ± 4.22 [16, 30] a |
28.37 ± 2.09 [21, 30] |
28.81 ± 2.26 [17, 30] |
| Retrospective ADNI-MEM |
0.33 ± 1.16 [−2.31, 2.08] a |
0.31 ± 0.61 [−0.55, 1.51] a |
0.73 ± 0.7 [−0.56, 1.95] a |
1.19 ± 0.66 [−0.04, 2.57] |
| Baseline ADNI-MEM |
0.10 ± 0.96 [−2.38, 2.01] a, b |
0.19 ± 0.62 [−1.19, 1.21] a |
0.55 ± 0.66 [−0.84, 1.69] a |
0.93 ± 0.56 [−0.40, 2.10] |
| Prospective ADNI-MEM |
−0.03 ± 1.08 [−2.56, 2.08] a, b |
0.10 ± 0.82 [−1.39, 1.45] a |
0.53 ± 0.69 [−0.88, 1.79] a |
1.02 ± 0.70 [−0.24, 2.51] |
| Retrospective ADNI-EF |
0.51 ± 0.91 [−1.37, 2.25] a |
0.28 ± 1.19 [−1.48, 2.12] a |
0.78 ± 0.72 [−0.68, 2.47] |
1.07 ± 0.79 [−0.56, 2.73] |
| Baseline ADNI-EF |
0.04 ± 1.12 [−2.43, 2.99] a, c |
0.62 ± 1.01 [−1.40, 2.00] |
0.43 ± 0.88 [−2.78, 2.23] a |
0.94 ± 0.87 [−2.31, 2.72] |
| Prospective ADNI-EF | 0.0016 ± 1.19 [−2.91, 2.23] a |
0.61 ± 0.83 [−0.83, 1.99] |
0.24 ± 0.95 [−2.39, 1.59] a |
0.81 ± 0.92 [−2.25, 2.99] |
Data are reported as mean ± standard deviation [minimum, maximum]. Hypothesis testing was performed using the Kruskal–Wallis test for the continuous variables and Fisher exact test for the nominal variables. a significantly different from minimal tau pattern; b significantly different from cortical predominant pattern; c significantly different from limbic predominant pattern; AD Alzheimer’s disease; SD standard deviation; TAD typical AD pattern; LP limbic predominant pattern; CP cortical predominant pattern; MT minimal tau pattern; APOE apolipoprotein; MMSE Mini-Mental State Examination; ADNI-MEM composite cognitive scores for memory; ADNI-EF composite cognitive scores for executive function