Table 3.
Estimated rate of atrophy change as a function of baseline tau-PET patterns (continuous scale)
| Fixed effects | Entorhinal cortex | Neocortex |
|---|---|---|
| Estimate (SE) | Estimate (SE) | |
| Intercept | 5.24 (0.25) ** | 2.86 (0.08) ** |
| Age | −0.01 (0.003) ** | −0.003 (0.0009) ** |
| TR | −0.28 (0.04) ** | −0.05 (0.01) * |
| TP | 0.23 (0.04) ** | 0.04 (0.01) * |
| Typicality | −0.26 (0.08) ** | −0.04 (0.02) |
| Severity | −0.45 (0.06) ** | −0.08 (0.02) ** |
| TypicalityB × TR | 0.14 (0.02) ** | 0.02 (0.01) |
| TypicalityB × TP | −0.1 (0.02) ** | −0.0009 (0.01) |
| SeverityB × TR | 0.1 (0.01) ** | 0.02 (0.01) * |
| SeverityB × TP | −0.1 (0.02) ** | −0.03 (0.01) ** |
Changes in atrophy (thickness) are estimated by the linear mixed effects model with individual-specific intercepts. The linear mixed effects model was centered at TB. Longitudinal atrophy was modeled as the dependent variable. Age, time, TypicalityB, SeverityB, and interactions with time were modeled as fixed effects. The significant effects corresponding to p≤0.001 and p≤0.01 are marked by ** and * respectively. SE standard error in coefficient; TR retrospective timepoint; TP prospective timepoint, TypicalityB baseline typicality (proxied by E:N), SeverityB baseline severity (proxied by global tau-PET SUVR)