Table 4.
Estimated rate of atrophy change as a function of baseline tau-PET patterns (discrete scale)
| Fixed effects | Entorhinal cortex | Neocortex |
|---|---|---|
| Estimate (SE) | Estimate (SE) | |
| Intercept | 4.25 (0.23) ** | 2.68 (0.07) ** |
| Age | −0.01 (0.003) ** | −0.003 (0.001) * |
| TR | −0.004 (0.02) | −0.009 (0.01) |
| TP | −0.01 (0.02) | 0.004 (0.01) |
| TADB | −0.4 (0.06) ** | −0.08 (0.02) ** |
| LPB | −0.18 (0.08) * | −0.04 (0.02) |
| CPB | 0.01 (0.07) | −0.02 (0.02) |
| TADB × TR | 0.1 (0.03) ** | 0.03 (0.01) * |
| TADB × TP | −0.08 (0.03) * | −0.01 (0.01) |
| LPB × TR | 0.1 (0.04) * | 0.01 (0.02) |
| LPB × TP | −0.09 (0.04) * | −0.002 (0.01) |
| CPB × TR | 0.02 (0.03) | 0.01 (0.01) |
| CPB × TP | 0.001 (0.03) | 0.002 (0.01) |
Changes in atrophy (thickness) are estimated by the linear mixed effects model with individual-specific intercepts. The linear mixed effects model was centered at TB and minimal tau pattern. Longitudinal atrophy was modeled as the dependent variable. Age, time, tau-PET pattern at baseline (TADB, LPB, CPB), and interactions of the patterns with time were modeled as fixed effects. The significant effects corresponding to p≤0.001 and p≤0.05 are marked by ** and * respectively. SE standard error in coefficient; TR retrospective timepoint; TP prospective timepoint, TADB typical AD pattern at baseline, LPB limbic predominant pattern at baseline, CPB cortical predominant pattern at baseline