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. 2023 Feb 22;42:50. doi: 10.1186/s13046-023-02621-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — A Lymphopoiesis and myelopoiesis pathways from common progenitors. Legend: HSC, MPP, CLP, CMP, Neu, and Mono: hematopoietic stem cells, multipotent progenitors, common lymphoid progenitors, common myeloid progenitors, neutrophils, and monocytes, respectively. From CLP and CMP, lymphoid and myeloid differentiation and maturation are separately processed. B Interactions of neutrophils and Th-17: T-helper 17 cells. Legend: Chemokines secreted by neutrophils induce IL-17 secretion by Th-17. IL-17 induces granulopoiesis, upregulates G-CSF, thereby inducing the differentiation and mobilization of neutrophils from progenitors within the bone marrow. This results in increasing neutrophil levels in the blood