Lateralization performance of CESTR, T1, and T2for the sMRI-negative (A, B, C) and sMRI-positive (D, E, F) patients. (A) The AUCs of different metrics calculated using the difference (M1) and ratiometric (M2) asymmetry measurements for sMRI-negative patients, with corresponding ROC curves shown in (B) and (C) for M1 and M2, respectively. (D–F) The AUC results and associated ROC curves for sMRI-positive patients. The laterality prediction of CESTR in the sMRI-negative (AUC: 0.83), sMRI-positive (AUC: 0.84), and total (AUC: 0.84) patients is relatively stable. The laterality accuracy of CESTR in the sMRI-negative patients is much higher than that of T1 and T2, while for the sMRI-positive patients, T2 is the best predictive index, with a slightly higher AUC (0.87) than that of CESTR (0.84).