Fig. 6.

Experimental (dotted line) and simulated (solid line) CESTR spectra in the HA ipsilateral to the epileptic focus at two saturation powers (1 and 4 μT). The CESTR curves were simulated with the normal HA parameters listed in Table 3A except for varying the concentration of the MT (A), amide (B), guanidinium (C), amine (D), hydroxyl (E), or NOE (F) pool according to Table 3B, in order to generate the minimum difference between experimental and simulated CEST contrasts. An increase of 25% in the amine concentration yielded the simulated spectra closest to the experimental ones.