Table 3.
Metabolic contributors revealed by the modified two-stage Bloch-McConnell fitting method.
| (A) First stage | MT | Amide | Guanidinium | Amine | Hydroxyl | NOE |
|---|---|---|---|---|---|---|
| Fraction (%) | 3.67 | 0.19 | 0.020 | 0.010 | 0.005 | 1.34 |
| Exchange rate | 20 | 45 | 250 | 1000 | 3000 | 9 |
| (B) Second stage | mRMSE | Percentage of change |
|---|---|---|
| MT fraction | 0.2622 | −42% |
| Amide fraction | 0.2671 | 9% |
| Guanidinium fraction | 0.2394 | 34% |
| Amine fraction | 0.2345 | 25% |
| Hydroxyl fraction | 0.2398 | 400% |
| NOE fraction | 0.2745 | −4% |
(A) First stage: results of the 12 parameters fitted to the CESTR spectra acquired from the normal HA using the 7-pool Bloch–McConnell equation. (B) Second stage: the minimum root mean squared error (mRMSE) achieved between the simulated and experimental signals (difference of CESTR spectra between the epileptogenic and normal HA) by varying the concentration of the MT, amide, guanidinium, amine, hydroxyl, or NOE pool alone each time. The percentages of change corresponding to the mRMSE were listed in the third column. The smaller the mRMSE, the higher the possibility that the associated metabolite contributed to the experimental results observed.