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. 2023 Feb 21;13:3007. doi: 10.1038/s41598-023-29991-1

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative k_io and K^trans parameter maps and the last frame of DCE-MR images of a mouse from the control group (left) and one from the treated group (right). The parameter maps are overlayed on the last frame of DCE-MR images (DCE). In both cases, it can be observed that the tumors grew aggressively within 4 days between Pre-tx and Tx-2.