Table 1.
Baseline characteristics of patients included in cluster-randomized analyses of the POINCARE-2 trial
| Control group, No. (%) (n = 472) | Strategy group, No. (%) (n = 433) | Stdiff | |
|---|---|---|---|
| Age, mean (SD), y | 65.7 (14.3) | 63.7 (14.1) | 0.15 |
| Male sex | 308 (65.3) | 278 (64.2) | 0.02 |
| Weight at ICU admission, mean (SD), kg | 79.4 (23.5) | 78.5 (20.0) | 0.04 |
| Height, mean (SD), cm | 169.8 (9.5) | 170.1 (9.4) | 0.03 |
| Mc Cabe scorea | 0.20 | ||
| Unknown | 32 | 31 | |
| A | 263/440 (59.8) | 279/402 (69.4) | |
| B | 143/440 (32.5) | 98/402 (24.4) | |
| C | 34/440 (7.7) | 25/402 (6.2) | |
| Coexisting conditions | |||
| Congestive heart failure | 38/452 (8.4) | 37/419 (8.8) | 0.02 |
| Chronic respiratory failure | 92/463 (19.0) | 80/423 (18.9) | 0.02 |
| Chronic kidney disease | 12/466 (2.6) | 8/425 (1.9) | 0.05 |
| Diabetes mellitus | 131/464 (28.2) | 102/425 (24.0) | 0.10 |
| Cirrhosis | 32/457 (7.0) | 26/419 (6.2) | 0.03 |
| Immunodeficiency | 64/463 (13.8) | 63/426 (14.8) | 0.03 |
| Cancer | 78/462 (16.9) | 78/422 (18.5) | 0.04 |
| SAPS II at day 1, median (IQR)b | 60.0 (47.0–72.0) | 56.0 (45.0–69.0) | 0.15 |
| SOFA score at admissionc, median (IQR) | 9.0 (6.0–12.0) | 9.0 (6.0–11.0) | 0.08 |
| Serum sodium level, mean (SD), mmol/L | 137.8 (6.7) | 138.1 (6.6) | 0.03 |
| Serum potassium level, mean (SD), mmol/L | 4.2 (1.0) | 4.0 (0.9) | 0.22 |
| Serum bicarbonate level, mean (SD), mmol/L | 20.8 (7.4) | 22.0 (6.4) | 0.17 |
| Serum creatinine level, median (IQR), mg/dL | 1.1 (0.7–1.9) | 1.0 (0.7–1.7) | 0.10 |
| PaO2:FiO2, mean (SD), mmHg | 216.9 (140.8) | 214.5 (133.3) | 0.02 |
| Main cause of admission | 0.23 | ||
| Septic shockd | 88 (18.6) | 70 (16.2) | |
| ARDS or acute respiratory failure | 172 (36.4) | 151 (34.9) | |
| Heart failure | 36 (7.6) | 22 (5.1) | |
| Acute renal failure | 10 (2.1) | 8 (1.8) | |
| Post-surgery | 14 (3.0) | 20 (4.6) | |
| CNS injury | 118 (25.0) | 139 (32.1) | |
| Other | 34 (7.2) | 23 (5.3) | |
| Vasopressors at day 0 | 268 (56.8) | 236 (54.5) | 0.05 |
| Renal replacement therapy at day 0 | 33 (7.0) | 25 (5.8) | 0.05 |
| ICU length of stay, median (IQR), days | 12 (8–20) | 11 (7–21) |
Stdiff denotes standardized difference (absolute value)
ARDS Acute respiratory distress syndrome, CNS Central nervous system, ICU Intensive care unit, IQR Interquartile range
aMcCabe score of A indicates no underlying disease that compromises life expectancy, B an estimated life expectancy with the chronic disease of less than 5 years, and C an estimated life expectancy with the chronic disease of less than 1 year. bSimplified Acute Physiology Score (SAPS) II ranges from 0 to 164, with higher scores indicating greater severity of symptoms. cSepsis-related Organ Failure Assessment (SOFA) score ranges from 0 to 24, with higher scores indicating more severe organ failure. dSeptic shock was defined as sepsis-related hypotension despite emergency fluid loading, requiring a vasopressor