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. 2023 Feb 22;14:12. doi: 10.1186/s13293-023-00494-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Associations of BMI with platelet parameters. BMI body mass index; CI confidence interval; MPV mean platelet volume; PDW platelet distribution width; Post-MP post-menopausal women; Pre-MP pre-menopausal women; SD standard deviation. SD_differences (95% CI) in platelet parameters per one SD increment of BMI from multivariable linear regression models including each platelet parameter as an outcome variable (sex-specific z-scores, following log-transformation) and BMI, ABSI, and HI as exposure variables (sex-specific z-scores), with adjustment for height, age, weight change (last year), smoking status (except for subgroups by smoking status), alcohol consumption (except for subgroups by alcohol consumption), physical activity, Townsend deprivation index, region of the assessment centre, time of blood collection, fasting time, use of nonsteroidal anti-inflammatory drugs, paracetamol use, menopausal status (women overall), hormonal replacement therapy use (women overall and Post-MP), oral contraceptives use and age at the last live birth (all women). Numerical values are shown in Additional file 1: Table S3. ^Ap value for the interaction term of BMI with sex, from a model including women (reference) and men (separately for subgroups by alcohol consumption and smoking status), with adjustment for ABSI, HI, covariates (except female-specific), and including an interaction term of age with sex, to account for potential differences by menopausal status in women. ^Bp value for the interaction term of BMI with menopausal status, from a model including Pre-MP (reference) and Post-MP women, with adjustment for ABSI, HI, and covariates. ^Cp value for the interaction term of BMI with age (continuous), from a model including all men, with adjustment for ABSI, HI, and covariates (except female-specific). ^W/M p value (women/men) derived from likelihood ratio tests comparing models with and without an interaction term of BMI with either alcohol consumption or smoking status, separately for women and men, with adjustment for ABSI, HI, and covariates. p values - p ≥ 0.05; *p < 0.05; **p < 0.001; ***p < 1 × 10^–6