Table 3.
Associated factors and independent predictors for AITD on univariable and multivariable analysis
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| Variable | OR | 95% CI | OR | 95% CI |
| Family history of AITD | 7.43 | 4.56 – 11.74c | 6.84 | 4.07 – 11.14c |
| Female sex | 2.36 | 1.42 – 4.19c | 2.22 | 1.25 – 4.25c |
| ANA positive | 1.77 | 1.16 – 2.71c | 1.99 | 1.25 – 3.18c |
| Age at JIA onset in years | 1.10 | 1.05 – 1.15c | 1.12 | 1.07 – 1.18c |
| Observation period in yearsa | 1.02 | 0.98 – 1.07 | ||
| Ethnicity | ||||
| European | 1.00 | Reference | ||
| Sub-Saharan African | – | – | ||
| Hispanic | 0.32 | 0.02 – 1.44 | ||
| Indian | 0.55 | 0.03 – 2.48 | ||
| Middle Eastern | 1.22 | 0.30 – 3.30 | ||
| Multiethnic | 0.72 | 0.04 – 3.29 | ||
| North African | 1.04 | 0.17 – 3.32 | ||
| Southeast Asian | – | – | ||
| Other | 1.68 | 0.09 – 7.80 | ||
| Family history of autoimmune disease | 2.59 | 1.71 – 3.93c | ||
| ILAR category | ||||
| Oligoarthritis | 1.00 | Reference | ||
| Enthesitis-related arthritis | 0.87 | 0.37 – 1.80 | ||
| Polyarthritis (RF-) | 1.34 | 0.81 – 2.21 | ||
| Polyarthritis (RF+) | 2.62 | 1.17 – 5.31c | ||
| Psoriatic arthritis | 2.14 | 0.80 – 4.81 | ||
| Systemic arthritis | 0.22 | 0.03 – 0.71c | ||
| Undifferentiated arthritis | 1.53 | 0.68 – 3.09 | ||
| Active joint count at diagnosisb | 0.99 | 0.82 – 1.07 | ||
| RF positive | 2.49 | 1.15 – 4.73c | ||
| HLA-B27 positive | 0.71 | 0.31 – 1.43 | ||
| Drug history at last visita | ||||
| NSAIDs | 0.87 | 0.54 – 1.49 | ||
| Intraarticular corticosteroids | 1.01 | 0.68 – 1.52 | ||
| Systemic corticosteroids | 0.71 | 0.46 – 1.09 | ||
| cs-DMARDs | 0.96 | 0.55 – 1.81 | ||
| Methotrexate | 0.83 | 0.51 – 1.43 | ||
| b-DMARDs | 1.24 | 0.80 – 1.95 | ||
| Anti-TNF | 1.49 | 0.98 – 2.32 | ||
AITD autoimmune thyroid disease, ANA anti-nuclear antibodies, b biological, CI confidence interval, cs conventional synthetic, DMARD disease-modifying antirheumatic drug, HLA human leukocyte antigen, ILAR International League of Associations for Rheumatology, JIA juvenile idiopathic arthritis, NSAIDs nonsteroidal anti-inflammatory drugs, OR odds ratio, RF rheumatoid factor, TNF tumor necrosis factor
aNot considered for multivariable analysis due to missing AITD onset dates
bOnly available for patients from the prospective cohort and therefore not considered for multivariable analysis
cstatistically significant effect