Table 3.  .

Methods of Repurposing [4]

Method	Required knowledge#
Blinded search or screening method	Off-label use Phenotypic screening
Target-based methods	Phenotypic screening; Target 3D structure, chemical structure information of drugs and ligands
Knowledge-based methods	Drug–target information, chemical structure information of targets and adverse effects (clinical trial information) Regulatory approval labels and adverse effects Available pathway information of disease
Signature-based methods	Disease omics data; Genetics data; Drug omics data Disease omics and drug omics data
Pathway- or network-based methods	Disease omics data, available pathway information, and protein interaction network; Drug omics data
Targeted mechanism-based methods	Drug omics data, disease pathway and protein interaction network

^# Repurposing methods require various skills and knowledge of various factors, that is, it may be drug-oriented or disease-oriented, or    treatment-oriented [4]