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Structural mapping of disease-related mutations in human Nav1.6. (A) Mapping of the disease-associated mutations on the structure of Nav1.6 in two perpendicular views. The Cα atoms of the disease-related residues are shown as spheres and colored for different types of disease. DEE13 (purple); BFIS5 (blue); MYOCL2 (red). (B) Mapping of the disease-related mutations in each domain of human Nav1.6.
