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. 2023 Jan 23;120(5):e2208344120. doi: 10.1073/pnas.2208344120

Fig. 4.

Fig. 4.

Antidepressants cause chromosomal mutations and multidrug resistance. Circos figure indicates the genes where SNPs happen chromosomally. (A) Bacterial population sequencing results. Circles from innermost to outermost are 50 mg/L sertraline 15 d-, 50 mg/L sertraline 30 d-, 50 mg/L sertraline 60 d-, 50 mg/L duloxetine 15 d-, 50 mg/L duloxetine 30 d-, 50 mg/L duloxetine 60 d-, 100 mg/L bupropion 30 d-, 100 mg/L escitalopram 30 d-, and 100 mg/L agomelatine 30 d-exposed bacterial population, respectively, with biological triplicate. (B) Mutant sequencing results. Circles from innermost to outermost are mutant strains of 1 mg/L sertraline-induced mutants on chloramphenicol-, tetracycline-selective plates (60-d exposure), 50 mg/L sertraline-induced mutants on chloramphenicol-, tetracycline-, ciprofloxacin-, amoxicillin-selective plates (60-d exposure), 50 mg/L sertraline-induced mutants on chloramphenicol-, tetracycline-selective plates (1-d exposure), and 50 mg/L sertraline-induced mutants on chloramphenicol-selective plate (30-d exposure), respectively, with biological triplicate. See also SI Appendix, Tables S14 and S15.