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. 2023 Jan 23;120(5):e2208344120. doi: 10.1073/pnas.2208344120

Fig. 8.

Fig. 8.

Antidepressants induce resistance to multiple antibiotics and enhance antibiotic persistence. (A) Overall bacterial evolution with and without antidepressant dosage. (B) Possible mechanisms illustrating the process: antidepressants increase bacterial intracellular ROS generation, enhance bacterial stress response, alter bacterial membrane, activate efflux pumps, and stimulate TA modules.