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Emax Model Parameters Characterizing the Relationship Between Efficacy and Different PK/PD Indices of LYSC98
| Parameters | Emax | E0 | EC50 | γ | R2 |
|---|---|---|---|---|---|
| Cmax/MIC | −3.76 | 1.04 | 5.32 | 9.99 | 0.8941 |
| AUC0–24h/MIC | −6.79 | 0.50 | 42.90 | 3.34 | 0.7793 |
| %T>MIC | −2.16 | 0.47 | 0.13 | 9.39 | 0.5424 |
Notes: The efficacy of each group was measured by comparing the bacterial load with the untreated group 24 hours later.
