Table 2.

Included Study Details and Characteristics

Study	Country	Design	Sample	Setting	Age, Years Mean (SD), or Median [IQR]	Female (%)	CFS Version	CFS Cut-Off	Pre-Hospital Frailty (%)
Anand et al 202028	UK	P	198	TC	79 (6)	42	7-item	CFS ≥5	20
Bagshaw et al 201443	Canada	P	421	ICU	67 (10)	39	9-item	CFS ≥4	33
Basic & Shanley 201544	Australia	P	2125	TC	83 (8)	60	7-item	CFS ≥5	89
Chan et al 201929	Canada	R	423	TC	83 (8)	63	9-item	CFS ≥6	83
Cheung et al 201730	Canada	R	260	TC	77 (8)	47	7-item	CFS ≥6	14
Chong et al 2017, 201831,32	Singapore	P	206	TC	89 (5)	70	9-item	CFS ≥5	81
Chua et al 202045	Singapore	P	314	ED	84 (7)	60	9-item	CFS ≥5	65
Curtis et al 201846	US	R	1403	TC	78 (9)	NS	7-item	NS	NS
Darvall et al 201947	Australia	R	15613	ICU	85 [82–88]	47	9-item	CFS ≥5	40
Darvall et al 20204	Australia	P	218	TC	74 [69–80]	45	9-item	CFS ≥5	28
Ekerstad et al 2011, 2014, 201833–35	Sweden	P	307	TC	83 (NS); 85 (NS)	49	7-item	CFS ≥5	49
Ellis et al 202036	UK	P	2254	ED	85 (14)	55	9-item	CFS ≥5	91
Evans et al 201949	UK	P	433	TC	83 [77–86]; 87 [83–92]	48–63	9-item	CFS ≥5	54
Fernando et al 201937	Canada	P	1510	TC	73 (7); 80 (8)	44	9-item	CFS ≥5	34
Flaatten et al 201750	ESICM	P	5021	ICU	84 [81–86]	48	9-item	CFS ≥5	43
Fronczek et al 201851	Poland	P	272	ICU	84 [81–87]	59	9-item	CFS ≥5	63
Guidet et al 202052	ESICM	P	3920	ICU	84 [81–87]	47	9-item	CFS ≥5	40
Lewis et al 201938	Australia	P	899	ED	80 (8)	51	7-item	CFS ≥5	44
Li et al 201839	Canada	P	308	TC	75 [65–94]	45	7-item	CFS ≥5	22
MacKenzie et al 201953	Canada	P	400	TC	81 (8)	57	9-item	CFS ≥5	79
Moore et al 201840	UK	R	924	TC	85 (9); 87 (9)	54–69	9-item	CFS ≥5	71–84
Ritt et al 201741	Germany	P	305	TC	85 (7); 82 (6)	60–70	9-item	CFS ≥5	72
Silva-Obregon et al 202054	Spain	R	285	ICU	78 (4)	38	9-item	CFS ≥5	19
Sze et al 201755	UK	P	265	TC	80 [72–86]	38	9-item	CFS ≥4	53
Ticinesi et al 201956	US	R	118	TC	84 (5)	61	7-item	CFS ≥5	45
Wallis et al 201542	UK	R	5764	TC	84 (6)	56	9-item	CFS ≥5	57

Abbreviations: ESICM (European Society of Intensive Care Medicine) includes Austria, Belgium, Cyprus, Czech Republic, Denmark, France, Germany, Greece, Italy, Libya, the Netherlands, Norway, Poland, Portugal, Romania, Russia, Spain, Sweden, Switzerland, Turkey, United Kingdom; P, prospective; R, retrospective; ICU, intensive care unit; ED, emergency department; TC, tertiary care including specialized medical care, trauma care, surgical care, University Hospitals, or tertiary referral hospitals; NS, not stated; SD, standard deviation; IQR, interquartile range.