TABLE 1.
Clinical features and correlations to GLS, HIF1-α, mTOR, TNF, p53 for the 29 ezetimibe targeted genes marked by the Comparative Toxicogenomics Database and Drugbank.
| Target genes | Gene expression difference between colon cancer and normal tissue | Gene expression difference between colon cancer stages | Correlation between gene expression and overall survival | Correlations between ezetimibe targeted genes and key energy metabolism indicators in colon cancer | ||||
|---|---|---|---|---|---|---|---|---|
| GLS | HIF1-α | mTOR | TNF | P53 | ||||
| NPC1L1 | — | F value 0.488 pr (>F) 0.691 | Logrank p 0.44 | p0.95 R0.0036 ** | p0.31 R0.058 | p0.29 R-0.06 | p0.5 R-0.038 | p0.33 R0.054 |
| HMGCR | * | F value 0.987 pr (>F) 0.399 | Logrank p 0.097 | p0.37 R0.051 | p0.0085 R0.15 ** | p3.1e-7 R0.28 *** | p0.85 R-0.011 | p0.28 R0.062 |
| APOA1 | — | F value 0.406 pr (>F) 0.749 | Logrank p 0.24 | p0.0013 R0.18 ** | p0.54 R-0.034 | p0.67 R-0.024 | p0.79 R-0.015 | p0.19 R-0.074 |
| LDLR | * | F value 1.12 pr (>F) 0.34 | Logrank p 0.3 | p0.27 R0.063 | p9.1e-7 R0.27 *** | p0.00035 R0.2 *** | p0.059 R0.11 | p0.097 R0.094 |
| SREBF2 | — | F value 0.816 pr (>F) 0.487 | Logrank p 0.27 | p0.13 R0.086 | p0.0061R0.15 ** | p8.9e-16 R0.43 *** | p0.011 R0.14 * | p0.33 R0.055 |
| ABCB11 | — | F value 1.53 pr (>F) 0.207 | Logrank p 0.94 | p0.029 R-0.12 * | p0.61 R-0.029 | p0.44 R-0.044 | p0.9 R-0.0068 | p0.0025 R-0.17 ** |
| CRP | - | F value 1.03 pr (>F) 0.38 | - | p0.55 R-0.034 | p0.42 R-0.045 | p0.11 R-0.089 | p0.91 R-0.0064 | p0.059 R0.11 |
| SREBF1 | — | F value 0.355 pr (>F) 0.785 | Logrank p 0.29 | p0.016 R-0.14 * | p4.2e-6 R0.26 *** | p1.3e-5 R0.24 *** | p0.42 R0.045 | p1.1e-6 R0.27 *** |
| TNF | — | F value 0.739 pr (>F) 0.53 | Logrank p 0.22 | p0.71 R0.021 | p0.001 R0.18 ** | p0.057 R0.11 | - | p0.96 R0.0027 |
| ABCA1 | * | F value 0.687 pr (>F) 0.561 | Logrank p 0.23 | p0.098 R0.093 | p<0.001 R0.54 *** | p5.3e-7 R0.28 *** | p2.3e-5 R0.24 *** | p0.025 R-0.13 * |
| NR1H2 | — | F value 1.55 pr (>F) 0.201 | Logrank p 0.26 | p0.012 R-0.14 * | p0.0051 R0.16 ** | p0.07 R0.1 | p0.00017 R0.21 *** | p0.065 R -0.1 |
| PCSK9 | * | F value 0.6 pr (>F) 0.615 | Logrank p 0.67 | p0.67 R-0.024 | p6.4e-5 R0.22 *** | p2.4e-5 R0.24 *** | p0.46 R0.042 | p4.2e-5 R0.23 *** |
| PGR | * | F value 3.64 pr (>F) 0.0133 * | Logrank p 0.021 * | p0.14 R-0.082 | p0.0037 R0.16 ** | p0.06 R0.11 | p0.31 R0.057 | p0.0034 R-0.16 ** |
| PLA2G7 | * | F value 1.57 pr (>F) 0.198 | Logrank p 0.85 | p0.0094 R0.15 ** | p<0.001 R0.45 *** | p0.00026 R0.2 *** | p2.4e-9 R0.33 *** | p0.64 R-0.026 |
| RARG | - | F value 1.49 pr (>F) 0.218 | Logrank p 0.55 | p0.064 R0.1 | p0.17 R0.077 | p0.00024 R0.21 *** | p0.64 R0.026 | p0.61 R0.029 |
| SCARB1 | * | F value 0.917 pr (>F) 0.433 | Logrank p 0.33 | p0.011 R0.14 * | p0.015 R-0.14 * | p0.27 R0.062 | p0.45 R-0.043 | p0.003 R0.17 ** |
| UGT1A1 | — | F value 1.57 pr (>F) 0.197 | Logrank p 0.91 | p0.68 R0.023 | p0.42 R-0.046 | p0.35 R-0.063 | p0.64 R-0.026 | p0.011 R-0.14 * |
| UGT1A3 | - | F value 2.61 pr (>F) 0.0519 | Logrank p 0.26 | p0.0011 R0.18 ** | p0.14 R-0.083 | p0.26 R-0.064 | p0.57 R-0.032 | p0.091 R-0.095 |
| UGT2B15 | - | F value 0.058 pr (>F) 0.982 | Logrank p 0.027 * | p0.00038 R-0.2 *** | p0.63 R0.027 | p0.88 R-0.0087 | p0.9 R0.0072 | p0.00039 R-0.2 *** |
| UGT2B7 | — | F value 2.48 pr (>F) 0.0681 | Logrank p 0.041 * | p0.61 R0.029 | p0.93 R-0.0046 | p0.82 R-0.013 | p0.53 R-0.036 | p0.85 R0.011 |
| SOAT1 | — | F value 0.45 pr (>F) 0.717 | Logrank p 0.69 | p0.039 R0.12 * | p8.9e-16 R0.43 *** | p6.8e-6 R0.25 *** | p0.0022 R0.17 ** | p0.64 R0.027 |
| ANPEP | — | F value 0.127 pr (>F) 0.944 | Logrank p 0.21 | p0.42 R0.046 * | p0.73 R-0.02 | p0.74 R-0.019 | p0.93 R-0.0052 | p0.0023 R-0.17 ** |
| CYP3A4 | — | F value 0.615 pr (>F) 0.606 | Logrank p 0.25 | p0.0022 R0.17 ** | p0.5 R-0.038 | p0.51 R-0.037 | p0.82 R-0.013 | p0.12 R-0.087 |
| CYP2C8 | — | F value 0.324 pr (>F) 0.808 | Logrank p 0.32 | p0.049 R0.11 * | p0.71 R-0.021 | p0.87 R-0.0089 | p0.96 R-0.0031 | p0.096 R-0.094 |
| ABCC2 | — | F value 0.912 pr (>F) 0.436 | Logrank p 0.28 | p2.8e-8 R0.31 *** | p0.054 R-0.11 | p0.22 R0.069 | p0.21 R-0.071 | p0.34 R0.054 |
| ABCB1 | — | F value 1.54 pr (>F) 0.204 | Logrank p 0.42 | p0.0036 R0.16 ** | p0.062 R-0.11 | p0.84 R0.011 | p0.98 R-0.0012 | p0.17 R-0.078 |
| ABCC3 | * | F value 4.67 pr (>F) 0.00338 ** | Logrank p 0.62 | p0.0056 R-0.16 ** | p0.24 R-0.067 | p1e-6 R0.27 *** | p0.97 R-0.0019 | p0.095 R-0.094 |
| SLCO1B1 | — | F value 1.59 pr (>F) 0.193 | Logrank p 0.26 | p0.37 R-0.051 | p0.5 R0.0038 | p0.32 R-0.056 | p0.5 R-0.038 | p0.014 R0.14 * |
| ABCG2 | — | F value 0.831 pr (>F) 0.478 | Logrank p 0.7 | p0.96 R-0.0028 | p0.32 R-0.056 | p0.19 R-0.073 | p0.3 R0.058 | p7.1e-5 R-0.22 *** |