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. Author manuscript; available in PMC: 2023 Feb 22.
Published in final edited form as: J Cell Physiol. 2020 Sep 22;236(4):2893–2905. doi: 10.1002/jcp.30053

FIGURE 3.

FIGURE 3

TMP269 pretreatment significantly improves lung function and heart rate in LPS challenged mice. (a) and (b) Mice were intravenously injected either with TMP269 (2.5 mg/kg) or saline (vehicle) followed by intratracheal injection of 1 mg/kg LPS. After 16 h, transcutaneous oxygen saturation (a) and heart rate (b) were monitored via a small animal pulse oximeter by placing the noninvasive sensor on the neck. (c) Lung function was measured after TMP and LPS treatment using Felxivent (Scireq). Values are mean ± SEM, n = 4–6. ***p < .0001, **p < .005; *p < .05 vehicle versus LPS; ###p < .0001, #p < .05 LPS versus TMP269/LPS. LPS, lipopolysaccharide