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. Author manuscript; available in PMC: 2023 Feb 22.
Published in final edited form as: J Cell Physiol. 2020 Sep 22;236(4):2893–2905. doi: 10.1002/jcp.30053

FIGURE 8.

FIGURE 8

Schematic illustration of proposed mechanisms of Class IIa HDACs involvement in LPS-induced ALI. The Class IIa HDAC inhibitor attenuates the effect of LPS-induced ECs hyperpermeability which involves ArgBP2-mediated activation of Rho signaling. ALI, acute lung injury; EC, endothelial cell; HDACs, histone deacetylases; LPS, lipopolysaccharide