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. 2023 Feb 21;107(3):709–719. doi: 10.1097/TP.0000000000004324

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Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 2. — Relationships between MMDx rejection categories, DSA and %dd-cfDNA. A, Boxplots showing the distribution of %dd-cfDNA values across central DSA categories. Boxes represent the interquartile ranges and horizontal lines the medians. B, DSA-negative category split into PRA-positive and PRA-negative categories. C, Venn diagram showing overlap of samples with Molecular Microscope Diagnostic System TCMR, ABMR, %dd-cfDNA ≥1, and DSA positivity. Samples with mixed rejection are in the intersection between AMR and TCMR. One hundred thirty-three of the 280 samples have none of the 4 features and are therefore outside of the ellipses. AMR, antibody-mediated rejection; dd-cfDNA, donor-derived cell-free DNA; DSA, donor-specific antibody; PRA, panel-reactive antibody; PRAHR, panel-reactive antibody–high risk; TCMR, T cell–mediated rejection.