TABLE 2.
Diagnoses in 280 biopsies grouped by DSA status
| Biopsy groups | Number of biopsies | ||
|---|---|---|---|
| DSA-negative (N = 220) | DSA-positivea (N = 60) | Total | |
| MMDx diagnoses | |||
| No rejection | 147 | 17 | 164 |
| Possible TCMR | 6 | 0 | 6 |
| TCMR | 15 | 5 | 20 |
| Possible AMR | 7 | 3 | 10 |
| AMR | 36 | 25 | 61 |
| Mixed (AMR + TCMR) | 9 | 10 | 19 |
| All AMR (including mixed) (% of row total) | 45 | 35 | 80 |
| Automated rejection (K1208) archetype | |||
| No rejection | 150 | 19 | 169 |
| TCMR1 (many mixed) | 4 | 5 | 9 |
| TCMR2 | 15 | 6 | 21 |
| Early AMR | 21 | 8 | 29 |
| Full AMR | 16 | 20 | 36 |
| Late AMR | 14 | 2 | 16 |
| All AMR | 51 | 30 | 81 |
| Histology diagnoses | |||
| No rejection | 112 | 8 | 120 |
| Possible TCMR | 28 | 1 | 29 |
| TCMR | 22 | 7 | 29 |
| Possible AMR | 16 | 12 | 28 |
| AMR | 23 | 21 | 44 |
| Mixed (AMR + TCMR) | 7 | 8 | 15 |
| All AMR (including mixed) | 30 | 29 | 59 |
| Missing | 12 | 3 | 15 |
Bolding indicates rows with AMR, mixed. Bolding and italics indicate All AMR.
a
Includes PRAHR. Biopsies from PRA-positive patients with missing/unavailable donor phenotyping to assign DSA status were called PRAHR in this study and were analyzed as DSA-positive.
AMR, antibody-mediated rejection; DSA, donor-specific antibody; MMDx, Molecular Microscope Diagnostic System; PRA, panel-reactive antibody; PRAHR, panel-reactive antibody–high-risk biopsy, TCMR, T cell–mediated rejection.