TABLE 8.
Predicting molecular antibody-mediated rejection/mixed considering only DSA, %dd-cfDNA, dd-cfDNA quantity, and TxBx
| Predictor variable(s) | P | AUC |
|---|---|---|
| TxBx | 4.4 × 10–3 | 0.61 |
| DSA | 3.2 × 10–8 | 0.66 |
| %dd-cfDNA | <1 × 10–16 | 0.84 |
| Quantity dd-cfDNA | <1 × 10–16 | 0.85 |
| %dd-cfDNA + DSA | <1 × 10–16 | 0.86 |
| %dd-cfDNA + DSA + quantity dd-cfDNA | <1 × 10–16 | 0.87 |
| %cfDNA + DSA + quantity dd-cfDNA + TxBx | <1 × 10–16 | 0.88 |
| Model comparison | P a | Interpretation |
| Quantity dd-cfDNA + %dd-cfDNA vs %dd-cfDNA | 0.007 | Quantity dd-cfDNA adds to %dd-cfDNA |
| %dd-cfDNA + quantity dd-cfDNA vs quantity dd-cfDNA | 0.01 | %dd-cfDNA adds to quantity dd-cfDNA |
| DSA + %dd-cfDNA vs %dd-cfDNA | 9.5 × 10–4 | DSA adds to %dd-cfDNA |
| DSA + %dd-cfDNA vs DSA | <1 × 10–16 | %dd-cfDNA adds to DSA |
| Quantity dd-cfDNA + %dd-cfDNA + DSA vs %dd-cfDNA + DSA | 0.0065 | Quantity dd-cfDNA adds slightly to %dd-cfDNA + DSA |
| TxBx + DSA + quantity dd-cfDNA + %dd-cfDNA vsDSA + quantity dd-cfDNA + %dd-cfDNA | 0.0018 | TxBx adds to DSA + quantity dd-cfDNA + %dd-cfDNA |
a
Likelihood ratio test.
AUC, area under the curve; dd-cfDNA, donor-derived cell-free DNA; DSA, donor-specific antibody;TxBx, time of biopsy posttransplant.